Glucosamine 200 Injection

Glucosamine hydrochloride 200 mg/mL

Glucosamine is utilised in the production of glycosaminoglycans (GAGs) which then combine with hyaluronic acid (HA) to form large proteoglycans in the matrix of cartilage. As such, glucosamine is a fundamental molecule for the synthesis and structure of cartilage.

A growing body of evidence supports the pain-relieving and potentially chondroprotective properties of glucosamine. Notably, glucosamine prevents degradation of cartilage proteoglycans. Glucosamine has also been shown to protect against the inhibition of proteoglycan production in chondrocytes caused by methylprednisolone. 

Oral administration of glucosamine and chondroitin sulfate has demonstrated positive effects on equine osteoarthritis and intravenous administration of glucosamine more rapidly produces significantly higher serum and synovial fluid glucosamine levels.  During one 12-hour study period, intravenous administration in horses created maximum glucosamine levels 50x higher in the serum and over 20x higher in the synovial (joint) fluid than oral administration of glucosamine HCl.

In Australian trials of NV GLUCOSAMINE 200 Injection, veterinarians reported “Good” to “Very Good” response in 67.5% of the osteoarthritic horses treated (20mL IV daily for 5 – 10 days in most cases). Positive responses included improved action and race performance, and reduced lameness and joint effusion.

Pentosan polysulfate, as contained in Ceva’s PENTOSAN EQUINE Injection, is known to stimulate cartilage healing6, a process which utilises glucosamine for production of GAGs and HA.

References

1. Fenton et al, Osteoarthritis Cartilage 2000 Jul;8(4):258-65
2. Byron et al, Am J Vet Res. 2008 Sep;69(9):1123-8
3. Laverty et al, Arthritis Rheum 2005;52:181-191
4. Du et al, Biopharm Drug Dispos 2004;25:109-116
5. McIlwraith, W, AAEP Proceedings (Milne Lecture) 2005;51.
6. Meulyzer et al, Osteoarthritis Cartilage 2008 Sep;16(9):973-9
7. Data on file

For use in selected cases to help improve joint function in horses.

Horses:

• (500 kg horse) Administer 20 mL daily by intravenous injection for 5 – 10 days, or as directed by a veterinary surgeon.

Camels:

• Administer 20 mL daily by intravenous injection for 5 – 10 days, or as directed by a veterinary surgeon.

Users must adhere to local and racing regulations.

WARNINGS: Always consult label and leaflet for restraints, contraindications, precautions and side effects.