Pentosan Gold Injection

Pentosan Polysulfate Sodium 125 mg/mL 

NAG (Acetyl Glucosamine) 200 mg/mL

PENTOSAN GOLD Injection contains Pentosan Polysulfate Sodium (PPS) which stimulates joint healing and repair, and reduces inflammation, to help reverse the effects of osteoarthritis; as well as NAG (Acetyl Glucosamine) a more advanced form of glucosamine that has been shown to improve glycosaminoglycan and hyaluronic acid synthesis compared with glucosamine. 

PENTOSAN GOLD possesses anti-inflammatory, anti-arthritic and chondroprotective properties. 

These beneficial effects arise from:

• direct anti-inflammatory activity
• inhibition of neutrophil migration into joints
• stimulation of hyaluronic acid (HA) synthesis by synovial fibroblasts which results in a marked increase in synovial fluid volume and viscosity
• stimulation of chondrocytes, and the biosynthesis of proteoglycans
• a strong fibrinolytic activity which improves the circulation in subchondral bone and periarticular structures, removing much of the source of pain.

Treatment using the combination of anti-arthritic agents Pentosan Polysulfate Sodium and NAG (Acetyl Glucosamine) in PENTOSAN GOLD may result in a greater anti-inflammatory effect than either active alone, which helps reduce joint swelling and improve mobility.

A field trial was conducted to compare the response to PPS along with PENTOSAN GOLD (PG) in horses. Twenty one field cases, presented to veterinarians for joint disease were used. In this trial the response to Pentosan Gold was better than Pentosan alone when treating the symptoms of osteoarthritis. The improvements in the measured variables, response time, effusion, flexion and overall response were higher for PG than for PPS indicating a greater anti-arthritic effect overall.  There was a tendency for a greater improvement in the flexion response with PG.

There were also a larger number of horses which showed reduced joint effusion for PG: 89% showed reduced joint effusion Overall horses treated with PENTOSAN GOLD showed greater improvements in the symptoms of joint disease than horses treated with PPS alone.

REFERENCES

1. Shikhman AR, et al. 2005 Ann. Rheum. Dis. 64;89-94.
2. Heinecke LF, et al. 2010 ACVIM Forum, Anaheim CA, Poster 404.
3. McConaghy FF, Perkins NR. 2012 Proc. Australasian Equine Sc. Symp. 4;50.

To aid in the treatment of non-infectious, inflammatory joint disease in horses.

In particular:

1. Osteoarthritis – especially with involvement of multiple joints
2. Osteochondrosis dissecans (OCD)
3. Traumatic joint and peri-articular inflammation

Horses:

• 3 mg/kg Pentosan polysulfate sodium
• 4.8 mg/kg Acetyl-Glucosamine 
• This equates to 12 mL/500 kg horse by intramuscular (IM) injection
•  Give every 5-7 days for 4 injections.

Vets recommend monthly booster injections following the 4 week course.  Ensure to repeat the course annually.  

Camels:

• 12mL (1 vial) Pentosan Gold for a large camel 
• 6 mL Pentosan Gold for a small camel
• Give every 5-7 days for 4 injections

Vets recommend monthly booster injections following the 4 week course.  Ensure to repeat the course annually.  

Users must adhere to local and racing regulations.

WARNINGS: Always consult label and leaflet for restraints, contraindications, precautions and side effects.