Readyserve

Oral Liquid: Altrenogest 2.2 mg/mL in a medium chain triglyceride solution

Injection: Altrenogest 50 mg/mL

Altrenogest acts similarly to the natural hormone progesterone by suppressing the normal sexual cycle and preventing signs of heat and ovulation. Mares return to heat and release natural hormones again once treatment stops. Treatment with altrenogest makes it possible to finely regulate the breeding of mares.

The newer injectable form has recently been developed. Pharmacokinetic studies have shown blood levels of altrenogest are maintained for 5 – 7 days following administration of the injection. Studies have been conducted to support supression of oestrus in cycling mares for 5 – 7 days following administration of READYSERVE Injection.

Oral Liquid:

1. For regulation and control of the breeding cycle of mares

• To induce ovulatory oestrus early in the breeding season in mares where some follicular activity exists
• To suppress oestrus either during prolonged oestrus or in normally cycling mares
• To control the ovarian cycle in breeding mares to allow the most efficient use of the stallion

2. For the maintenance of pregnancy in habitually aborting mares, or mares at risk of early embryonic death or abortion, where progesterone deficiency is thought to be the underlying cause.

Injection:

For the suppression of oestrus in normally cycling mares for 5 – 7 days.

Oral Liquid:

Administer 1 mL per 50 kg bodyweight (0.044 mg/kg altrenogest) daily.

1. For regulation and control of the breeding cycle of mares

• To induce ovulatory oestrus or to induce cyclical ovarian activity in mares with some follicular activity early in the breeding season; administer daily for 10 consecutive days
• To suppress oestrus in normally cycling mares; administer daily for 15 consecutive days. To suppress prolonged oestrus; administer daily for 10 consecutive days.
• To control the breeding cycle of mares to allow the most efficient use of the stallion; administer daily for 15 consecutive days.

2. For the maintenance of pregnancy in habitually aborting mares, or mares at risk of early embryonic death or abortion; administer daily from the 2nd or 3rd day after ovulation in the mated or inseminated mare, continuing daily until day 120 of gestation.

NOTE: Ultrasound scanning to confirm pregnancy is recommended on day 14 or 15 after ovulation. If the mare is not pregnant, cease READYSERVE administration and administer an injection of prostaglandin F2 to destroy any remnant luteal tissue, allowing the mare to return to oestrus and be re-mated. Injection: 3 mL/500 kg adult mare every 5 – 7 days by intramuscular injection.